Endocrine Abstracts

Background:In thyroid autoimmune conditions such as Graves' disease, thyroid cells die by apoptosis (programmed cell death).Dysregulation of pro- and anti-apoptotic genes may be critical to the induction of the destructive process via the activation of a sequence of caspases (proteases). Conventionally, apoptosis occurs via 2 main pathways: the Intrinsic pathway mediated by mitochondria and the Extrinsic pathway mediated by the activation of death receptors (Fas and TN...